Cell Migration and Urokinase Plasminogen Activator Expression in a Mouse Blood-Flow Ablation of MEK Kinase 1 Suppresses Intimal Hyperplasia by Impairing Smooth Muscle
نویسندگان
چکیده
Okada, Yoko Nagamachi, Masashi Fujita, Akio Hirata, Shoji Sanada, Hiroshi Asanuma, Seiji Yan Li, Tetsuo Minamino, Osamu Tsukamoto, Toshiaki Yujiri, Yasunori Shintani, Ken-ichiro Cessation Model Cell Migration and Urokinase Plasminogen Activator Expression in a Mouse Blood-Flow Ablation of MEK Kinase 1 Suppresses Intimal Hyperplasia by Impairing Smooth Muscle Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000160350.20810.0F 2005;111:1672-1678; originally published online March 28, 2005; Circulation. http://circ.ahajournals.org/content/111/13/1672 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model.
BACKGROUND Migration, proliferation, and matrix-degrading protease expression of smooth muscle cells (SMCs) are major features of intimal hyperplasia after vascular injury. Although MEK kinase 1 (MEKK1) has been shown to regulate cell migration and urokinase plasminogen activator (uPA) expression, the precise role of MEKK1 in this process remains unknown. METHODS AND RESULTS We triggered a va...
متن کاملModulation of smooth muscle cell migration by members of the low-density lipoprotein receptor family.
Low-density lipoprotein receptor family members (LRs) play a key role in the catabolism of many membrane-associated proteins, such as complexes between proteinases and their receptors, in addition to being involved in lipoprotein metabolism as suspected by the hitherto well-established functions of low-density lipoprotein receptor, in a variety of tissues. Recent studies using receptor-deficien...
متن کاملPharmacological Targeting of Plasminogen Activator Inhibitor-1 Decreases Vascular Smooth Muscle Cell Migration and Neointima Formation.
OBJECTIVE Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor that promotes and inhibits cell migration, plays a complex and important role in adverse vascular remodeling. Little is known about the effects of pharmacological PAI-1 inhibitors, an emerging drug class, on migration of vascular smooth muscle cells (SMCs) and endothelial cells (ECs), crucial mediators of vascular ...
متن کاملA secreted soluble form of LR11, specifically expressed in intimal smooth muscle cells, accelerates formation of lipid-laden macrophages.
OBJECTIVE Macrophages play a key role in lipid-rich unstable plaque formation and interact with intimal smooth muscle cells (SMCs) in early and progressive stages of atherosclerosis. LR11 (also called sorLA), a member of low-density lipoprotein receptor family, is highly and specifically expressed in intimal SMCs, and causes urokinase-type plasminogen activator receptor-mediated degradation of ...
متن کاملRecombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia.
OBJECTIVE Plasminogen activator inhibitor-1 (PAI-1) overexpression is implicated in vascular disease. However, the effects of a primary increase in PAI-1 expression on arterial remodeling are poorly defined. We tested the hypothesis that recombinant PAI-1 inhibits intimal hyperplasia after vascular injury. METHODS AND RESULTS Rats underwent carotid artery injury and received intraperitoneal i...
متن کامل